Designing colloidal nanoparticle and nanodrug for cell therapy

26 Novembre 2024
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Nikhil R. Jana
School of Materials Science, Indian Association for the Cultivation of Science, Kolkata
Email: camnrj@iacs.res.in
Group Homepage: https://iacs.res.in/athusers/index.php?navid=0&userid=IACS0042

Aula Riunioni DII
Piano Terra
Via Caruso 16 Pisa

Abstract
In past few decades there is significant advancement in biomedical applications of various nanoparticles. Current chalenges include designing nanoparticle that can readily cross the cell membrane, target different subcellular compartments and control intracellular processes. We design colloidal nanoparticle/nanodrug of 10-100 nm size and use them to control various cellular processes and for cell therapy. 1-5 We found that cellular uptake and intracellular function can be controlled by appropriately designed nanoparticle/nanodrug. We show that nanoparticle can be designed for energy-independent direct cell translocation (without endocytosis) or preferencial lipid raft/caveolai-mediated endocytosis as compared to conventional clathrin- mediated endocytosis. Adapting these principles we design nanodrugs that can readily enter into cell, label different subcellular compartments and offers enhanced therapeutic performance. This talk will summarize our effort in this area, highlight the importance of nanodrug design and their application for sub-cellular delivery/targeting/therapy.
References
1. Jana, N. R. Colloidal Nanoparticles: Functionalization for Biomedical Applications, CRC Press, 2019.
2. Debnath, K.; Pal, S.; Jana, N. R. Acc. Chem. Res. 2021, 54, 2916-2927.
3. Dolai, J.; Mandal, K.; Jana, N. R. ACS Appl. Nano Mater. 2021, 4, 6471-6496.
4. Debnath, K.; Sarkar, A. K.; Jana, Nihar R.; Jana, Nikhil R. Acc. Mater. Res. 2022, 3, 54-66.
5. Sarkar, A. K.; Shaw, S.; Arora, H.; Seth, P.; Jana, N. R. Nano Lett 2024, 24,13473–13480.

 

Bio
MS and PhD: Indian Institute of Technology-Kharagpur, India
Postdoc: University of South Carolina and University of Arkansas, USA
Awards& Honours:
1) Member, Editorial Board, ACS Applied Materials and Interfaces, 2016-2019
2) Associate Editor, ACS Applied Nano Materials since 2019

Professor Nikhil R. Jana received his PhD in chemistry from Indian Institute of Technology-Kharagpur in 1994. He was a postdoctoral fellow at University of South Carolina (1999-2001) with Professor Catherine J. Murphy and at University of Arkansas (2003) with Professor Xiaogang Peng.
He moved to Singapore in 2004 and worked as a Scientist at the Institute of Bioengineering and Nanotechnology, until he returned to India in 2008 and began his independent research carrier at Indian Association for the Cultivation of Science (IACS). He is currently Professor at School of Materials Science at IACS.
His laboratory focuses on chemical synthesis of colloidal nanobioconjugate and their application as bioimaging nanoprobe and for prevention/curing of neurodegenerative diseases.
He has authored or co-authored about 220 peer-reviewed articles and 3 books on basic and applied nanoscience, with a primary focus on tuning of nanoparticle surface chemistry toward various biomedical applications.