TARA - Disrupting the Migraine continuum of care for resource constrained settings

Horizon Europe

Start Date: 1 September 2022
End date: 31 August 2025

Project coordinator: Massimo Piotto

Project website: https://www.tara-project.eu/

Chronic migraine is defined as a headache persistent for more than 3 months or a severe headache persistent for more than 15 days within a month. It affects approximately 2% of the world population. 
The World Health Organization classifies severe migraine attacks as among the most disabling illnesses, comparable to dementia and quadriplegia. Treatments start with pharmaceutical drugs, which have contra-indications and severe side effects and often remain ineffective in chronic migraine patients. Injectable treatments like Botox and nerve blocks can be effective but require multiple sessions per year and also have undesirable effects.
Treatments using neurostimulation products that deliver electrical pulses to the occipital nerve have been up to 80% effective but they are designed for the back not the neck which results in high rates of surgical revisions. This leaves the chronic migraine population severely underserved and in need of an innovative solution.
Our vision is fundamentally based on disrupting the continuum of care and referral pathway by creating a more effective non-surgical solution that reduces cost and risk and therefore increases accessibility to more physicians and patients.
The consortium will develop a novel platform for the treatment of chronic migraine that will be particularly applicable to resource restricted environments and targeting underserved patients. We are working on 4 elements working together seamlessly.

1) A neurostimulation implantable device

2) A wearable device that will power the implantable device.

3) A mobile app to control the implant.

4) A delivery catheter that reduces tissue trauma and training required for physicians.



  1. UNIVERSITÀ DI PISA (UNIPI), PIC 999862712, Dipartimento di Ingegneria dell'Informazione, established in via G. CARUSO, 16 56122 PISA, Italy, the Coordinator
  2. CAPRI MEDICAL LIMITED (CAPRI), PIC 904741602 with legal address Capri Medical @ Flynn O'Driscoll Business Lawyers, 1 Grant's Row, Lower Mount Street, Dublin 2,Dublin,Ireland, Beneficiary, Technical Lead
  3. SENSICHIPS SRL (SENSICHIPS), PIC 938969701 with legal address Via delle Valli 46, 04011 Aprilia (LT), Italy, Beneficiary
  4. CROWDHELIX LIMITED  (CHX), PIC 905205165 with legal address Russell & Co., Trinity House 7 Georges Quay, T12NAX0 Cork, Ireland, Beneficiary
  5. UNIVERZITETNI KLINICNI CENTER MARIBOR (SB MARIBOR) PIC 999582188 with legal address Ljubljanska ulica 5, 2000 Maribor, Slovenia,  Beneficiary
  6. BRAI3N (BRAI3N) PIC 889451880, with legal address Jemappesstraat 5, 9000 Ghent, Belgium, Beneficiary
  7. SKEIN-UKRAINE (SKEIN-UKRAINE) PIC 894226996, with legal address 18 PYROHOVSKOGO ST, KYIV 03037, Ukraine, Beneficiary
  8. EUROPEAN SOCIETY OF REGIONAL ANAESTHESIA AND PAIN THERAPY (ESRA), PIC 912719367, with legal address Rue de Chantepoulet 10, 1201 Geneva, Switzerland, Associated Partner
  9.  SOUTH TEES HOSPITALS NHS FOUNDATION TRUST (STH), PIC 950365261, with legal address Marton Road, Middlesbrough, TS4 3BW, United Kingdom, Associated Partner
  10.  CENTRE FOR PROCESS INNOVATION LIMITED LBG (CPI), PIC996621069, with legal address Wilton Centre, Wilton, Redcar, TS10 4RF, United Kingdom, Associated Partner